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青年博士-张寿德



   张寿德

副教授 硕士生导师

shoude.zhang@qhu.edu.cn

青海大学 国家重点实验室220

学术兼职

中华全国青年联合会第十三届委员中国青年科协理事青海省青年科技协会副会长Chinese Journal Natural Product青年编委北大核心《中医科学杂志(英文)》青年编委



研究方向

1)中藏药活性成分发现与制备

2)药物筛选方法研究

3)药物与蛋白质相互作用研究

个人经历

工作经历

2017.4-至今 青海大学三江源生态与高原农牧业国家重点实验室 副教授

2014.12-2016.10 瑞典卡罗林斯卡学院(Karolinska Institutet) 博士后

2012.07-2017.03 华东理工大学药学院 讲师

2006.08-2007.08 第二军医大学现代中药研究中心 科研助理


学习经历

2007.09-2012.07 上海交通大学 药学院 博士学位

2002.09-2006.07 第二军医大学 药学院 获学士学位

科研项目

12021.1-2024.12 “角蒿中哌啶类单萜生物碱靶向调控肌动蛋白细胞骨架组装抗肿瘤的作 用机制和构效关系研究,国家自然科学基金,地区科学基金项目 ,项目编号: 22067016 ,经费:41

22021.1-2023.12“中药锁阳中PDE5抑制剂的制备工艺研究及改善性能产品的研发,青海省重点研发与转化计划项目,项目编号:2021-QY-203, 经费:100

32018.1-2020.12“藏波罗花中生物碱类成分的抗肿瘤活性及其作用机理研究,青海省自然基金青年项目,经费:20

42017.6-2019.6“黄花角蒿生物碱类成分的抗肿瘤活性及其作用机理研究,青海大学三江源生态与高原农牧业国家重点实验室自主课题,经费:10

52014.1-2016.12“倍半萜内酯类化合物Britain抗自身免疫性心肌炎的作用机制研究国家自然科学青年基金项目,项目编号:81302651,经费:25

学术成就

已发表论文

[1] Wang Y, Li Z, Liu B, Wu R, Gong H, Su Z, Zhang S*. Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages. Drug Design, Development and Therapy 2020:14 1–7.

[2] Haifeng Gong, Juan An, Qiuxia Dong, Jinxian Li, Wei Yang, Wei Sun, Zhanhai Su, Shoude Zhang*. Discovery of SCY45, a natural small-molecule MDM2-p53 interaction inhibitor. Chemistry & Biodiversity. 10.1002/cbdv.201900081.

[3] Shoude Zhang; Qiang Gao; Wei Li; Luwei Zhu; Qianhan Shang; Shuo Feng; Junmei Jia; Qiangqiang Jia; Shuo Shen; Zhanhai Su. Shikonin inhibits cancer cell cycling by targeting Cdc25s. BMC Cancer. 2019. 19:20

[4] Yaping Hua, Waqas Azeem, Yunheng Shen, Shoude Zhang, Jan R. Olsen, Anne M. Øyan, Xisong Ke, Weidong Zhang, Karl-Henning Kalland. Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain. Pharmacol Res Perspect. 2018, e00437. DOI: 10.1002/prp2.437. (2018.9.20)

[5] ShouDe Zhang, ZhanHai Su, RuiHui Liu, YanYan Diao, ShiLiang Li, Ya-Ping Hua, HongLin Li*, WeiDong Zhang*, Exploring the Pathways and Targets of Shexiang Baoxin Pill for Coronary Heart Disease through a Network Pharmacology Approach. World J Tradit Chin Med. 2018, 4(4): 137-146 (2018.11.10)

[6] Shoude Zhang*, Qiangqiang Jia, Qiang Gao, Xueru Fan, Yuxing Weng, Zhanhai Su*. Dual-Specificity Phosphatase CDC25B was inhibited by natural product HB-21 through covalently binding to the active site. Frontiers in Chemistry. Frontiers in Chemistry. 2018, 6:531 (2018.11.13)

[7] Yanyan Diao, Jing Jiang, Shoude Zhang, Shiliang Li, Lei Shan, Jin Huang, Weidong Zhang, Honglin Li*. Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening. Front. Chem., 2018. 6: 140

[8] Fang Bai, Kangdong Liu, Huiliang Li, Jiawei Wang, Junsheng Zhu, Pei Hao, Lili Zhu, Shoude Zhang, Lei Shan, Weiya Ma Ann M. Bode, Weidong Zhang*, Honglin Li*, Zigang Dong*. Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA. Nucleic Acids Res., 2018. 46(2): 546-557

[9] Guozhen Wu, Lili Zhu, Xing Yuan, Hao chen, Rui Xiong, Shoude Zhang, Hao Cheng, Yunheng Shen, Huazhang An, Tiejun Li, Honglin Li*, Weidong Zhang*. Britanin ameliorates cerebral ischemia–reperfusion injury by inducing the Nrf2 protective pathway. Antioxid. Redox Signal., 2017. 27(11): 754-768

[10] Shoude Zhang, Lei Shan, Wei Li, HongLin Li, WD Zhang. Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. Chinese Journal of Natural Medicines, 2015, 13 (9): 660-666

[11] Shoude Zhang, Lei Shan, Qiao Li, Xia Wang, Shiliang Li, Yuan Zhang, Jianjun Fu, Xiaofeng Liu, Honglin Li, and Weidong Zhang. Systematic Analysis of the Multiple Bioactivities of Green Tea through a Network Pharmacology Approach. Evid. Based Complement. Alternat. Med., 2014 : 512081

[12] Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan, Weidong Zhang. Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins. BMC Cancer, 2014. 14 : 689

[13] Shoude Zhang, Weiqiang Lu, Xiaofeng Liu, Yanyan Diao, Fang Bai, Liyan Wang, Lei Shan, Jin Huang, Honglin Li, Weidong Zhang. Fast and effective identification of the bioactive compounds and their targets form the medicinal plants via computational chemical biology approach. Med. Chem. Commun. 2011. 2: 471-477.

[14] Shoude Zhang, Jiangjiang Qin, Huizi Jin, Yinhua Yin, Honglin Li, Xianwen Yang, Xia Li, Lei Shan, Weidong Zhang. Sesquiterpenoids from Inula racemosa Hook. f. Inhibit Nitric Oxide Production. Planta Med. 2012. 78: 166-171.

[15] Xiangrong Cheng, Shoude Zhang, Chunhui Wang, Jie Ren, Jiangjiang Qin, Xue Tang, Yunheng Shen, Shikai Yan, Huizi Jin, Weidong Zhang. Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz. Phytochemistry, 2013. 96: 214-222

[16] Mengzhu Xue, Shoude Zhang, Chaoqian Cai, Xiaojuan Yu, Lei Shan, Xiaofeng Liu, Weidong Zhang, Honglin Li. Predicting the drug safety for TCM though a comprehensive analysis of withdraw drugs using pharmacological network. Evid.Based Compl. Alt. Med., 2013. 256782.

[17] Xianwen Cao, Jing Jiang, Shoude Zhang, Lili Zhu, Juan Zou, Yanyan Diao, Weilie Xiao, Lei Shan, Handong Sun, Weidong Zhang, Jin Huang, Honglin Li, Discovery of Natural Estrogen Receptor Modulators with Structure-based Virtual screening. 2013. Bioorg Med Chem Lett. 23:3329-3333.

[18] Zheng Wang, Shuai Luo, Shoude Zhang, Wulin Yang, Yangzi Liu, Honglin Li, Xiaoyan Luo, Weiping Deng. Catalytic Asymmetric Construction of Quaternary a-Amino Acid Containing Pyrrolidines through 1,3-Dipolar Cycloaddition of Azomethine Ylides to a-Aminoacrylates. Chem. Eur. J., 2013. 19: 6739-6745.

[19] Xia,Li, Shoude Zhang, Hui-Zi Jin, Feng Dong, Lei Shan, Wei-Dong Zhang. A new flavonol from Oxytropis ochrocephala Bunge. Nat Prod Res, 2013.6:554-557.

[20] YongLi Li, Shoude Zhang, HuiZi Jin, JunMian Tian, XianWen Yang, HongLin Li, and WeiDong Zhang. AbiestetranesA and B, two unique tetraterpenes from Abies fabri. Tetrahedro, 2012, 68: 7763-7767.

[21] Jia-Han Xia, Shou-De Zhang, Yong-Li Li, Liang Wu, Zhi-Jun Zhu, Xian-Wen Yang, Hua-Wu Zeng, Hong-Lin Li, and Wei-Dong Zhang. Sesquiterpenoids and Triterpenoids from Abies holophylla and Their Bioactivities. Phytochemistry, 2012, 74:178-184

[22] Ping Yu, Shou-De Zhang, Yong-Li Li, Xian-Wen Yang, Hua-Wu Zeng, Hong-Lin Li, and Wei-Dong Zhang. Abieseconordines A and B, two norditerpenoids with a 18-nor-5,10;9,10-diseco-abietane skeleton from Abies forrestii. Helv. Chim. Acta. 2012, 95, 415-422.

[23] Liyan Wang, Xi Li, Shoude Zhang, Weiqiang Lu, Sha Liao, Xiaofeng, Liu, Lei Shan, Xu Shen, Hualiang Jiang, Weidong Zhang, Jin Huang, Honglin Li. Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg Med Chem, 2012, 20: 4164-4171.

[24] Yanping, Gao, Yunheng Shen, Shoude Zhang, Junmian Tian, Huawu Zeng, Ji Ye, Huiliang Li, Lei Shan, Weidong Zhang. Incarvilleatone, a New Cyclohexylethanoid Dimer from Incarvillea younghusbandii and Its Inhibition against Nitric Oxide (NO) Release. Org Lett. 2012. 14, 1954-1957.

[25] Xiaojun Liu, Fang Liu, Rongcai Yue, Yuanyuan Li, Jigang Zhang, Shuping Wang, Shoude Zhang, Rui Wang, Lei Shan, Weidong Zhang. The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system. Pharmacol Biochem Be, 2013, 110: 224-230

[26] Jiangjiang Qin, Huizi Jin, Jiaxian Zhu, Jianjun Fu, Qi Zeng, Xiangrong Cheng, Yan Zhu, Lei Shan, Shoude Zhang, Yuexin Pan, Weidong Zhang. New sesquiterpenes from Inula japonica Thunb. with their inhibitory activities against LPS-induced NO production in RAW264.7 macrophages. Tetrahedron. 2010, 66, 9379-9388.

[27] Siyang Fan, Yuehu Pei, Huawu Zeng, Shoude Zhang, Yongli Li, Li Li, Ji Ye, Yuexin Pan, Honglin Li, Weidong Zhang. Compounds from Platycladus orientalis and Their Inhibitory Effects on Nitric Oxide and TNF-α Production. Planta Med. 2011, 77, 1623-1630.

[28] Cheng, Xiangrong; Qin, Jiangjiang; Zeng, Qi; Zhang, Shoude; Zhang, Fei; Yan, Shikai; Jin, Huizi; Zhang, Weidong. Taraxasterane-Type Triterpene and Neolignans from Geum japonicum Thunb. var. chinense F. Boll. Planta Med . 2011, 77, 2061-2065.

[29] Cheng, Xiangrong; Zeng, Qi; Ren, Jie; Zhang, Shoude; Shen, Yunheng; Zhu, Jiaxian; Zhang, Fei; Chang, Ruijie; Zhu, Yan; Zhang, Weidong; Jin, Huizi. Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents. Eur J Med Chem, 2011, 46, 5408-5415.

授权发明专利

[1] 发明人:张寿德。名称:一种具有治疗神经退行性疾病功效的化合物及药物组合物。申请号:CN201810994597

[2] 发明人:张寿德,专利名称:一种药物组合物及其用途,公开号:CN109078028A

[3] 发明人:张寿德,专利名称:一种药物组合物及其用途,公开号:CN104285783A

[4] 发明人:张寿德、张卫东、李洪林。名称:角蒿酯碱类化合物在制备抗乳腺癌药物中的应用。专利号:ZL201310727461.4

[5] 发明人:张寿德、张卫东。名称:双吨酮类化合物在制备治疗白血病药物中的应用。专利号:ZL201310727849.4

[6] 发明人:张卫东、于益芝、张寿德、戴先坤、曹雪涛、苏娟、李江燕、沈云亨、单磊。名称:菠萝花碱在制备抗自身免疫病和抗移植排斥疾病药物中的应用.。公开号:CN102008468

[7] 发明人:于益芝、张卫东、张寿德、曹雪涛、苏娟、戴先坤、李江燕、单磊。名称:氯化两面针碱在制备抗自身免疫病和抗移植排斥疾病药物中的应用. 公开号:CN102008474

[8] 发明人:于益芝、张卫东、苏娟、曹雪涛、单磊、戴先坤、李江燕、张寿德。名称:落叶松脂醇在制备抗自身免疫病和抗移植排斥疾病药物中的应用。公开号:CN101991566

[9] 发明人:黄瑾、张卫东、李洪林、单磊、张寿德、张燕燕、陈瞳、苏娟、李、辛伟。名称:紫草酸酯类化合物在制备治疗疟疾药物中的应用。公开号:CN101693028

[10] 发明人:单磊、黄瑾、张卫东、李洪林、苏娟、卢伟强、张寿德、陈瞳。名称:蔓生白薇C在制备治疗疟疾药物中的应用。公开号:CN101693036

[11] 发明人:张卫东、黄瑾、单磊、李洪林、王立言、张寿德、卢伟强、苏娟、陈瞳。名称:黄酮苷类化合物在制备治疗疟疾的药物中应用。公开号:CN101693037